With care, sandy lady after vacation (8)
I believe the answer is:
gingerly
'with care' is the definition.
(gingerly can mean carefully or cautiously)
'sandy lady after vacation' is the wordplay.
'sandy' becomes 'ginger' (hair colour).
'after vacation' says to hollow out the word (remove centre letters) (the inside letters must vacate).
'lady' with its middle removed is 'ly'.
'ginger'+'ly'='GINGERLY'
(Other definitions for gingerly that I've seen before include "In a careful manner" , "With soft steps" , "Cautiously (as if in pain?)" , "Showing caution" , "(Approach) in a cautious manner" .)