Worked in small room, changing the far end (6)

I believe the answer is:

toiled

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'worked' is the definition.
(toiling is a kind of working)

I can't explain the remainder of the clue.

(Other definitions for toiled that I've seen before include "Laboued long and hard" , "Worked laboriously and long" , "Struggled long and hard" , "Worked long and hard" , "Worked or laboured very hard" .)

I've seen this clue in The Times.

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