Worry is in past over Tyneside (7)
I believe the answer is:
agonise
'worry' is the definition.
(I've seen this before)
'is in past over tyneside' is the wordplay.
'in' is an insertion indicator.
'past' becomes 'ago' ('ago' can be similar in meaning to 'past'**).
'over' says to put letters next to each other.
'tyneside' becomes 'ne' (region in North East of England).
'ago'+'ne'='agone'
'is' put within 'agone' is 'AGONISE'.
(Other definitions for agonise that I've seen before include "Worry greatly (over something); I go sane (anag.)" , "Suffer torment" , "Suffer anguish - go in sea (anag)" , "Worry intensely" , "Be very worried" .)