You can trip on it in the desert (6)

I believe the answer is:

peyote

(Other definitions for peyote that I've seen before include "Hallucinogenic cactus; eye pot (anag.)" , "Hallucinogenic drug from Mexican cactus" , "Cactus hallucinogen" , "Mescal, a cactus" .)

I've seen this clue in The New York Times.

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