A longing to change tendon issue (8)
I believe the answer is:
ganglion
'tendon issue' is the definition.
Although both the answer and definition are singular nouns, I can't understand how they can define each other.
'a longing to change' is the wordplay.
'to change' indicates anagramming the letters.
'a'+'longing'='alonging'
'alonging' with letters rearranged gives 'GANGLION'.
Can you help me to learn more?
(Other definitions for ganglion that I've seen before include "Group of nerve cells from which fibres radiate" , "Collection of nerve cells" , "Swelling" , "centre of interest" , "Nerve centre" .)