At home nurse may be mean (6)
I believe the answer is:
intend
'be mean' is the definition.
(to intend to something is to mean it)
'at home nurse' is the wordplay.
'at home' becomes 'in' ('I'm in' can mean 'I'm at home').
'nurse' becomes 'tend' (tend can mean to nurse or look after).
'in'+'tend'='INTEND'
'may' is the link.
(Other definitions for intend that I've seen before include "Plan, propose" , "Tinned (anag.)" , "Signify" , "Mean; aim" , "Mean (to do something)" .)