Consecrated area guarded by son and daughter (6)
I believe the answer is:
sacred
'consecrated' is the definition.
(I know that consecrated can be written as sacred)
'area guarded by son and daughter' is the wordplay.
'area' becomes 'acre' (I've seen this before).
'guarded by' means one lot of letters goes inside another.
'son' becomes 's' (genealogical abbreviation for son).
'and' says to put letters next to each other.
'daughter' becomes 'd' (genealogical abbreviation).
's'+'d'='sd'
'acre' going inside 'sd' is 'SACRED'.
(Other definitions for sacred that I've seen before include "Like gravestones maybe" , "Hallowed, consecrated" , "Religious" , "'Hallowed, holy (6)'" , "Sanctified" .)