Could two males lead to havoc? (6)
I believe the answer is:
mayhem
'havoc?' is the definition.
('mayhem' can be a synonym of 'havoc')
'could two males lead' is the wordplay.
'two males' can mean two replacements for 'male'.
'could' becomes 'may' (I've seen this before).
'male' becomes 'he'.
'lead' indicates taking the first letters.
The initial letter of 'male' is 'm'.
'may'+'he'+'m'='MAYHEM'
'to' is the link.
(Other definitions for mayhem that I've seen before include "Carnage" , "Total chaos" , "Violent destruction of confusion" , "Havoc - chaos" , "Violent or damaging action, a crime" .)