Drama in family, tragically regal (4,4)
I believe the answer is:
king lear
'drama' is the definition.
(I've seen this before)
'family tragically regal' is the wordplay.
'family' becomes 'kin' (synonyms).
'tragically' indicates an anagram (I've seen this in other clues).
'regal' is an anagram of 'glear'.
'kin'+'glear'='KING LEAR'
'in' is the link.
(Other definitions for king lear that I've seen before include "Shakespeare's foolish tragic monarch" , "Tragic hero" , "Play set in medieval Britain" , "Shakespeare's foolish, fond old man" , "Shakespeare tragedy" .)