Drop everything for a fresh start (4)
I believe the answer is:
fall
'drop' is the definition.
(synonyms)
'everything for a fresh start' is the wordplay.
'everything' becomes 'all' (I've seen this before).
'for' means one lot of letters go next to another (I've seen this in other clues).
'start' indicates taking the first letters.
The first letter of 'fresh' is 'f'.
'all' put after 'f' is 'FALL'.
(Other definitions for fall that I've seen before include "rain?" , "Sudden decline" , "Collapse; decline" , "Drop, decrease" , "Autumn - trip" .)