Fancy woman sacrificing main artery to put weight on! (6)

I believe the answer is:

stress

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'put weight on' is the definition.
(I've seen this before)

I cannot understand how the remainder of the clue works.

(Other definitions for stress that I've seen before include "what causes tension" , "Highlight" , "'Strain, tension (6)'" , "Emphasis on anxiety?" , "Force" .)

I've seen this clue in The Times.

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