Female teacher with anxiety on motorway? (8)
I believe the answer is:
mistress
'female teacher' is the definition.
(schoolmistress)
'anxiety on motorway?' is the wordplay.
'anxiety' becomes 'stress' (anxiety is stress or tension).
'on' says to put letters next to each other.
'motorway?' becomes 'MI' (resembles M1, English motorway).
'stress' put after 'mi' is 'MISTRESS'.
'with' acts as a link.
(Other definitions for mistress that I've seen before include "Female owner of a dog" , "Lady" , "Husband's paramour" , "Schoolteacher" , "Quickly, maybe" .)