Female with spite putting male off (5)
I believe the answer is:
alice
'female' is the definition.
'male off' is the wordplay.
'male' becomes 'al' (shortened version of Alex or Alistair).
'off' becomes 'ice' (I am not sure about this - if you are sure you should believe this answer much more).
'al'+'ice'='ALICE'
'with spite putting' is the link.
I am not very happy about this link. Some or all of it may belong to another bit of the clue.
Can you help me to learn more?
(Other definitions for alice that I've seen before include "Girl famed for Wonderland adventures" , "Carroll heroine" , "Girl in literary Wonderland" , "... Walker, ... Munroe (writers)" , "She fell down a rabbit hole into a fantasy world" .)