Free about fifty with no trouble (7)
I believe the answer is:
release
'free' is the definition.
(to release someone is to free them)
'about fifty with no trouble' is the wordplay.
'about' becomes 're' (regarding).
'fifty' becomes 'l' (Roman numeral).
'with' says to put letters next to each other.
'no trouble' becomes 'ease' (I've seen this in another clue).
're'+'l'+'ease'='RELEASE'
(Other definitions for release that I've seen before include "put out" , "Free from confinement" , "record" , "Set free - publish" , "Free - delivery" .)