Insane and angry, like a milliner (2,3,2,1,6)
I believe the answer is:
as mad as a hatter
'insane' is the definition.
I know nothing about this answer so I can't tell whether this works.
'angry like a milliner' is the wordplay.
'angry' becomes 'asmad' (I can't justify this - if you can you should give a lot more credence to this answer).
'like' becomes 'as'.
'milliner' becomes 'hatter' (synonyms).
'asmad'+'as'+'a'+'hatter'='AS MAD AS A HATTER'
'and' is the link.
Can you help me to learn more?
(Other definitions for as mad as a hatter that I've seen before include "Troubled, as one responsible for tiles" , "having a tile loose?" .)