Itinerant Aussie without a family (5)
I believe the answer is:
issue
'family' is the definition.
(thesaurus)
'itinerant aussie without a' is the wordplay.
'itinerant' is an anagram indicator (I've seen this in other clues).
'without' indicates named letters should be taken away.
'aussie' with 'a' removed is 'ussie'.
'ussie' with letters rearranged gives 'ISSUE'.
(Other definitions for issue that I've seen before include "Result, outcome; topic" , "Outflow or point of concern" , "Give or send out" , "Children; topic for debate" , "Offspring or one of publication" .)