Lacking limbs is not dangerous in the East End (7)
I believe the answer is:
armless
'dangerous in the east end' is the definition.
I can't tell whether this defines the answer.
'lacking limbs is not' is the wordplay.
'lacking' means to remove the last letter (the word is incomplete or lacking).
'limbs' becomes 'arms' (arm is a kind of limb).
'is not' becomes 'less' (I've seen this in other clues).
'arms' with its final letter removed is 'arm'.
'arm'+'less'='ARMLESS'
Can you help me to learn more?
(Other definitions for armless that I've seen before include "Short of members" , "to equip? Not so" .)