Leaders of Great Ormond Street Hospital? I say! (4)
I believe the answer is:
gosh
'i say' is the definition.
Both the definition and answer are interjections.
Perhaps they are linked in a way I don't understand?
'leaders of great ormond street hospital?' is the wordplay.
'leaders of' indicates taking the first letters.
The initial letters of 'great ormond street hospital' is 'GOSH'.
Can you help me to learn more?
(Other definitions for gosh that I've seen before include "Exclamation of surprise" , "Well I'm blowed!" , "Cor!" , "I'm amazed!" , "Surprised expression" .)