Leading lady looking hot strayed from path (5)
I believe the answer is:
erred
'strayed from path' is the definition.
'leading lady looking hot' is the wordplay.
'leading lady' becomes 'er' (Elizabeth Regina).
'looking hot' becomes 'red'.
'er'+'red'='ERRED'
(Other definitions for erred that I've seen before include "Strayed from the straight and narrow" , "Made mistakes" , "was inaccurate" , "Committed a sin" , "Made mistake, was incorrect" .)