Live with earl, oddly bitter? (4)
I believe the answer is:
beer
'bitter?' is the definition.
(bitter is a type of beer)
'live with earl oddly' is the wordplay.
'live' becomes 'be' (synonyms).
'with' says to put letters next to each other.
'oddly' means one should take alternating letters (letters in odd-numbered positions).
The alternating letters of 'earl' are 'er'.
'be'+'er'='BEER'
(Other definitions for beer that I've seen before include "Drink brewed with malt" , "Drink flavoured with hops" , "Drink with a head" , "Ale, lager etc" , "Stout, for example" .)