Mark first man’s address to female (5)
I believe the answer is:
madam
'to female' is the definition.
(madam is a kind of female)
'mark first man's' is the wordplay.
'mark first' becomes 'm' (ast letter of 'mark').
'man' becomes 'adam' (man's name).
'm'+'adam'='MADAM'
'address' acts as a link.
I am not very happy about this link. It may be part of another bit of the clue.
Can you help me to learn more?
(Other definitions for madam that I've seen before include "How one may address a woman" , "pompous young lady?" , "Woman with status - girl with bad manners" , "Formal address to a woman - precocious little girl" , "Titled lady" .)