Meat in southeast is disgrace (5)
I believe the answer is:
shame
'is disgrace' is the definition.
(I've seen this in another clue)
'meat in southeast' is the wordplay.
'meat' becomes 'ham' (ham is a kind of meat).
'in' means one lot of letters goes inside another.
'southeast' becomes 'SE' (synonyms).
'ham' inserted inside 'se' is 'SHAME'.
(Other definitions for shame that I've seen before include "pity!" , "Disgrace, intense regret" , "show up" , "disgraceful" , "Disgrace, ignominy" .)