Might be a fool, you say, to leave (6)
I believe the answer is:
desert
'leave' is the definition.
(deserting is a kind of leaving)
I don't understand how the remainder of the clue works.
Can you help me to learn more?
(Other definitions for desert that I've seen before include "Abandon, waterless area" , "Kalahari, for example" , "merit and a > quiet place" , "ditch" , "Kalahari, e.g." .)