My rise has been ruined because of the depression (6)
I believe the answer is:
misery
'the depression' is the definition.
(thesaurus)
'my rise has been ruined because' is the wordplay.
'my rise' anagrams to 'MISERY'.
However, I am not clear how the anagram is indicated.
'of' acts as a link.
Can you help me to learn more?
(Other definitions for misery that I've seen before include "Distress, wretchedness" , "Great suffering" , "Feeling of great unhappiness" , "Wretchedness, suffering" , "Wretched unhappiness" .)