Outspoken genius rejects one scientist playing God (12)
I believe the answer is:
frankenstein
'scientist playing god' is the definition.
I can't tell whether this definition defines the answer.
'outspoken genius rejects one' is the wordplay.
'outspoken' becomes 'frank' (synonyms).
'genius' becomes 'einstein' (as in Albert Einstein).
'rejects' is a deletion indicator.
'one' becomes 'i' (Roman numeral).
'einstein' with 'i' taken out is 'enstein'.
'frank'+'enstein'='FRANKENSTEIN'
Can you help me to learn more?
(Other definitions for frankenstein that I've seen before include "Animator" , "Monster's creator" , "that could ruin manufacturer" , "Monstrous and dangerous humanoid" , "Mary Shelley's mad Swiss scientist" .)