Paint two animals, first of sketches framed (8)
I believe the answer is:
emulsion
'paint' is the definition.
(I've seen this before)
'two animals first of sketches framed' is the wordplay.
'two animals' means two substitutions for 'animal'.
'animal' becomes 'emu' (emu is a kind of animal).
'animal' becomes 'lion'.
'first of sketches' becomes 's' (1st letter of 'sketches').
'framed' indicates putting letters inside.
'lion' placed around 's' is 'lsion'.
'emu'+'lsion'='EMULSION'
(Other definitions for emulsion that I've seen before include "Mixture of insoluble liquids" , "Mixture involving two liquids which do not readily combine" , "Wall paint" , "Type of paint" .)