Protest ignited by institute concerned with ruin (10)
I believe the answer is:
demolition
'ruin' is the definition.
(I've seen this before)
'protest ignited by institute concerned' is the wordplay.
'protest' becomes 'demo' (demonstration).
'ignited' becomes 'lit' (synonyms).
'by' says to put letters next to each other.
'institute' becomes 'i' (common abbreviation as in MIT).
'concerned' becomes 'on' (I've seen this in other clues).
'demo'+'lit'+'i'+'on'='DEMOLITION'
'with' acts as a link.
(Other definitions for demolition that I've seen before include "ruin" , "explosion" , "destructive action" , "Licking" , "Knocking down" .)