Ruth and Ron's rum has nearly all gone (3,5)
I believe the answer is:
run short
'has nearly all gone' is the definition.
I can't tell whether this definition defines the answer.
'ruth and ron's rum' is the wordplay.
'and' is a charade indicator (letters next to each other).
'rum' is an anagram indicator (rum can mean strange or unusual).
'ruth' put after 'rons' is 'ronsruth'.
'ronsruth' is an anagram of 'RUN SHORT'.
Can you help me to learn more?
(Other definitions for run short that I've seen before include "become exhausted" , "Come to be lacking" , "Become lacking" .)