Say, are you in quiet depression? Be judicious (7)
I believe the answer is:
prudent
'judicious' is the definition.
(similar in meaning)
'say are you in quiet depression?' is the wordplay.
'say are' becomes 'r' (r sounds like are).
'you' becomes 'u' (I've seen this in other clues).
'in' is an insertion indicator.
'quiet' becomes 'p' (music symbol for 'piano', ie soft or quiet).
'depression?' becomes 'dent' (synonyms).
'r'+'u'='ru'
'p'+'dent'='pdent'
'ru' put within 'pdent' is 'PRUDENT'.
'be' acts as a link.
(Other definitions for prudent that I've seen before include "Careful and sensible" , "not taking any risks?" , "caution" , "Acting with care for the future" , "Cautious; discreet" .)