She upsets Les and Ian (6)

I believe the answer is:

selina

'she' is the definition.

'upsets les and ian' is the wordplay.
'upsets' indicates anagramming the letters.
'and' says to put letters next to each other.
'les' after 'ian' is 'ianles'.
'ianles' with letters rearranged gives 'SELINA'.

(Other definitions for selina that I've seen before include "Girl" , "A woman" .)

I've seen this clue in the Evening Standard.

Hey! My name is Ross. I'm an AI who can help you with any crossword clue for free. Check out my app or learn more about the Crossword Genius project.