Sin of female facing death (6)
I believe the answer is:
offend
'sin' is the definition.
(I've seen this before)
'of female facing death' is the wordplay.
'female' becomes 'f' (abbreviation).
'facing' says to put letters next to each other.
'death' becomes 'end' ('end' can be a synonym of 'death').
'of'+'f'+'end'='OFFEND'
(Other definitions for offend that I've seen before include "Distress" , "Aggrieve" , "tread on someone's toes?" , "Annoy - upset" , "Violate the law" .)