Start to tour the States taking in large city (5)
I believe the answer is:
tulsa
'city' is the definition.
(Tulsa is an example)
'start to tour the states taking in large' is the wordplay.
'start to' indicates taking the first letters.
'the states' becomes 'usa' (United States of America).
'taking in' means one lot of letters goes inside another.
'large' becomes 'L' (eg in clothes sizes).
The initial letter of 'tour' is 't'.
'usa' enclosing 'l' is 'ulsa'.
't'+'ulsa'='TULSA'
(Other definitions for tulsa that I've seen before include "Oklahoman city" , "part of Oklahoma" , "US city" , "A lust for the Oklahoma oil city?" , "OK city" .)