Strange to send nail East (5)
I believe the answer is:
alien
'strange' is the definition.
(synonyms)
'send nail east' is the wordplay.
'send' indicates an anagram (I've seen 'sending' mean this (letters are sent to different positions)).
'east' becomes 'e' (synonyms).
'nail'+'e'='naile'
'naile' with letters rearranged gives 'ALIEN'.
'to' acts as a link.
(Other definitions for alien that I've seen before include "Not native" , "Creature from another planet" , "One is from outer space, perhaps" , "Foreigner, outsider" , "Foreign - film directed by Ridley Scott" .)