The Birth of Venus is one of ____'s best-known paintings (10)
I believe the answer is:
botticelli
(Other definitions for botticelli that I've seen before include "Florentine C fifteen-sixteen artist (Primavera)" , "who painted?" , "Italian painter of The Birth of Venus, d. 1510" , "Italian painter, 1445-1510" , "Famous Italian" .)