"The Mother of Presidents” (4)
I believe the answer is:
ohio
'the mother of presidents' is the definition.
(I've seen this in another clue)
This is the entire clue.
(Other definitions for ohio that I've seen before include "American state, capital Columbus" , "Midwest US state" , "US state, joined in 1803" , "part of the Midwest!" , "The Buckeye State" .)