This might be the psychological state of doctor who had Omicron twice. (4)
I believe the answer is:
mood
'state of doctor who had omicron twice' is the definition.
'mood' can be an answer for 'state' (mood is a kind of state). I'm unsure of the rest of the definition.
I don't understand the remainder of the clue.
Can you help me to learn more?
(Other definitions for mood that I've seen before include "Disposition" , "Bad feeling" , "at times appears very high" , "Frame of mind" , "Doom (anag)" .)