Title role in 'Shrek' originally recalled (3)
I believe the answer is:
Here is my best explanation:
'title' is the definition.
'role in 'shrek' originally recalled' is the subsidiary indication.
'originally' suggests taking the first letters.
'recalled' is a reversal indicator.
The initial letters of 'role in shrek' is 'ris'.
'ris' reversed gives 'sir'.
(Other definitions for sir that I've seen before include "Title given to 10 Across", "... ___ John Major", "Honourable title", "Form of address for a knight", "Polite term of address for a man", "Male form of address", "Honorary male title", "Respectful address for a man", "Polite or formal address to male" and "Formal term of address".)