Crossword Genius

Vexation, distress (7)

Ross

I believe the answer is:

chagrin

This clue is a double definition.

'vexation' is the first definition.
(I've seen this in another clue)

'distress' is the second definition.
(thesaurus)

(Other definitions for chagrin that I've seen before include "irritation?" , "Embarrassment - rich nag (anag)" , "Annoyance/shame at one's failure" , "Arching with annoyance and embarrassment" , "Disappointment, exasperation" .)

I've seen this clue in The Guardian.
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