Weird sound emanating from a great lake (5)
I believe the answer is:
eerie
'weird' is the definition.
(both can mean strange or unsettling)
'emanating from a great lake' is the wordplay.
'emanating' becomes 'e' (this could be a standard abbreviation I've not previously seen).
'from' is a charade indicator (letters next to each other).
'a great lake' becomes 'erie' (Erie is one of the Great Lakes).
'e'+'erie'='EERIE'
'sound' acts as a link.
This may not be right. It may belong to another bit of the clue.
Can you help me to learn more?
(Other definitions for eerie that I've seen before include "Spooky, unearthly" , "Weird and disturbing" , "Scary, weird" , "Ghostly" , "Spooky, creepy" .)