Why the senora's upset? (6)
I believe the answer is:
reason
'why' is the definition.
(I've seen this in another clue)
'senora's upset?' is the wordplay.
'upset?' indicates an anagram (I've seen 'upsets' mean this).
'senora' with letters rearranged gives 'REASON'.
'the' is the link.
(Other definitions for reason that I've seen before include "Defence" , "Explanation; logic" , "Mental power to justify an act" , "Justification; sanity" , "Justification needed" .)