Working method required to cover large part of course (6)
I believe the answer is:
module
'part of course' is the definition.
(part of a university course)
'working method required to cover large' is the wordplay.
'working method' becomes 'MO' (modus operandi, a particular way of working).
'required' becomes 'due' (due can mean required or expected).
'to cover' indicates putting letters inside.
'large' becomes 'L' (eg in clothes sizes).
'due' enclosing 'l' is 'dule'.
'mo'+'dule'='MODULE'
(Other definitions for module that I've seen before include "Unit of a study course" , "Detachable compartment of a spacecraft" , "Complete part (of spacecraft or course)" , "Self-contained unit, of study perhaps" , "Detachable sub-unit" .)