Caretaker on vacation -- relax, and laugh like a drain! (6,2)
I believe the answer is:
crease up
'laugh like a drain' is the definition.
I know nothing about this answer so I cannot judge whether this works.
'caretaker on vacation relax' is the wordplay.
'on vacation' suggests removing the centre.
'relax' becomes 'easeup' (I've seen this in another clue).
'caretaker' with its centre removed is 'cr'.
'cr'+'easeup'='CREASE UP'
'and' acts as a link.
Can you help me to learn more?
(Other definitions for crease up that I've seen before include "Laugh a great deal" , "Bend in two with laughter" .)